مولد صوت AI Ghaemisa007 من Fish Audio

When we look at selective serotonin reuptake inhibitors, or SSRIs, the interesting finding is that even at quarter doses, some patients show significant response. This demonstrates, similar to lithium, that there's often therapeutic benefit even at lower doses than traditionally prescribed.

When we look at antidepressant efficacy studies, we're seeing this same pattern where lower doses, properly administered, can be just as effective. Why are we stuck in this mindset that more is always better? The research clearly shows that careful, precise dosing often yields better outcomes.

So the idea that antidepressants are always better than placebo is actually false. The studies show that in mild to moderate depression, the effect size is quite small, and at lower severity levels, the difference from placebo is almost negligible. The evidence clearly demonstrates this.