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So if we look at the liver function, let's say, over time you might see about, I'm approximating here, maybe 20-30% decline by age 70. That's normal aging, you know, similar to what we see in other organs, but the liver has this remarkable ability to regenerate, so that's different from, say, the kidneys.

Let's explore how the brain processes reward learning, because there's this interesting phenomenon where our neural circuits respond differently to expected versus unexpected rewards. Whether it's food, social media, or learning, these pathways shape our behavioral patterns in fascinating ways.

Consider how social media has created this unprecedented paradox where we're more connected than ever, yet studies show we're feeling more isolated. It's not just about the time spent online, it's about how we're processing these constant social comparisons and curated realities.

Welcome, to Matter of Fact. Each week, we examine the science behind a wellness-fad— or headline remedy—promised to heal body or mind.

So when we look at creatine supplementation, what does the research actually tell us? Well, if we examine the literature, we see consistently that it's one of the most well-studied supplements. Now, does this mean everyone needs it? No, but let's look at who might benefit most.

Looking at the work of Dr. Henderson in 1934, he documented interesting patterns in sleep architecture and how it relates to various psychiatric conditions, and he noticed that patients would show distinct circadian variations which really connects to what we understand about neurotransmitter function today.

When we look at human motivation, we find that self-driven individuals share distinct characteristics. They tend to set their own goals, resist external pressure, and maintain strong personal boundaries. This behavior stems from their deep-rooted need for independence and self-direction.

So, you know, in the early 2000s, we started seeing more specialized training programs in sleep medicine. The ACGME, they developed these new requirements, and, uh, the certification process became more standardized across different institutions.