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Исита

Hello, dear colleagues. I present to you a study on: "Evaluating the efficacy of injectable preparations in treating involutional changes of the face and neck, considering genetic markers and morphofunctional skin status." Next slide Scientists have proven that skin aging begins immediately after puberty. It becomes more noticeable between the ages of 35-50 and lasts until approximately 60 years of age. After that, a relatively stable period begins. Skin aging is a complex, multicomponent, multifactorial, and prolonged process. To date, there is no single definition of what skin aging is; however, it is already clear that it is caused by the accumulation of "defects" both in cells and in its intercellular structures. Next slide MAIN FACTORS OF AGING First, hereditary (genetically) programmed changes affecting almost all layers of the skin; Second, physiological (age-related) decline in hormone synthesis in the body. Hormones such as growth hormone, testosterone, DHEA (dehydroepiandrosterone), melatonin, etc., are essential for physical health and cell regeneration throughout the body, including the skin. Starting from the age of 20, the production of these hormones gradually decreases; And third, photoaging – exposure to ultraviolet rays promotes the formation of free radicals, which negatively affect skin cell structures, significantly altering cellular repair mechanisms. Next slide Involutional skin changes, particularly of the face and neck, are of special relevance in this aspect, being one of the first easily identifiable visual signs of the body's overall aging. Skin aging is a natural biological process occurring at the molecular, cellular, and tissue levels. The main manifestations of natural aging are thinning of the skin, increased skin texture and contrast pigmentation, moderate dryness, slight flaking, the presence of wrinkles acquiring characteristic forms for each age period. Next slide It is also important to note that the lifespan of extracellular matrix (ECM) proteins in general, and the system of elastic fibers in particular, determines the rate of molecular aging. Unlike intracellular proteins, whose half-life is measured in hours and days, the half-life of many extracellular proteins is on the order of several years. Therefore, to maintain youthful skin, it is necessary to protect its structural components and perform procedures that promote their active restoration. Human genes cannot be changed. But by studying their characteristics, we can prevent and reduce the impact of negative factors on a specific individual. Knowing the weak points in gene function, we can direct efforts precisely there and thus influence the manifestation of certain external signs. Next slide In my work, I paid special attention to key genes that directly influence signs of skin aging. These are genes responsible for the mechanical properties of the skin, as well as hydration and moisture loss. According to the research results: · The COL1A1 gene for detecting disorders in collagen structure – in most cases revealed impaired collagen fibril assembly. · The ELN gene, which is responsible for skin elasticity, was prevalent in the majority of observed patients, indicating a reduced level of elastin in the skin and blood vessels. · The AQP3 gene for hydration and moisture loss showed low levels of aquaporins in the subjects. Research is also ongoing to study the correlation between genetic aberrations and various morphotypes of aging. Next slide For more detailed diagnostic data on the superficial and deep layers of the skin, a comprehensive assessment was performed using the Courage & Khazaka Intelligent Imaging System, which allows for a detailed assessment of skin sebum, porosity, fine superficial wrinkles, chromophores, and skin color. It also assesses deeper indicators such as pigment, vascular patterns (red areas), pathology of capillaries, and collagen status. All these parameters were analyzed in accordance with the specific patient's genome. Based on this, therapy was selected for the patient. Next slide Histological examinations of the skin from the area of interest were also conducted before and after therapy. This slide shows characteristic morphological involutional changes: inflammatory infiltration represented by lymphocytes and plasma cells with a slight increase in the number of mast cells; dilation of lymphatic vessels with edema of varying severity is observed. Next slide In an older patient, the skin thickness was greater, which can be associated with an increase in the amount of mature collagen in the reticular layer. Also, a difference in the degree of vessel dilation, especially lymphatic vessels, can be noted in the presented samples. Next slide The preparations we selected for therapy based on all the presented diagnostic patient data are skin bioreparants with a patented formula for zinc delivery into the cell and water-soluble silicon to activate high-quality neocollagenesis. Thanks to the action of zinc, not only is the synthesis of new type 1 and type 3 collagen stimulated in the cell, but it also affects genetic stability by slowing down the process of telomere shortening, which leads to increased cell activity. The developed zinc delivery formula is a system of gel globules of high molecular weight (1800 kDa) hyaluronic acid with inclusions of low molecular weight fragments (60-80 kDa) of a metal complex (Zn+HA). Organic silicon, in turn, controls collagen formation at several "points": it stimulates mRNA synthesis, increases the enzymatic activity of prolyl hydroxylase, and promotes proline synthesis. This is necessary for the formation of the collagen triple helix, without which its full function is impossible. Next slide "Skinopro" preparations are a chelate complex in which the active components Zn(II)HA(20-60kDa) in the form of "hyasomes" (microscopic liquid-crystalline spherical, droplet-like particles) are uniformly distributed within the volume of high molecular weight HA (hydrogel). Next slide What functions do the components of the preparation perform? Zinc: Is a cofactor for a large group of enzymes, including metalloproteinases involved in extracellular matrix remodeling. · Has a proven positive effect on cellular aging biomarkers. · A powerful antioxidant, as superoxide dismutase (which regulates lipid peroxidation) is a zinc-containing enzyme. Silicon: Improves metabolic processes in cells. · Stimulates collagen formation. · Strengthens collagen structure (participates in the formation of the triple helix). · Increases the physiological activity of fibroblasts. · Regulates cellular metabolism. · Reduces the development of fibrosis and lowers the level of glycation. Next slide In terms of clinical effects, I noted the correction of dehydration, improved skin tone and turgor, wrinkle correction, and correction of soft tissue ptosis. Next slide Protocols: Skinopro Active and Skinopro Forte. We can work with these preparations using different techniques depending on the zone and indications for use. We also actively treat the neck area, including the central and lateral surfaces. Next slide Patient: 49 years old Diagnosis: Senile skin atrophy (L57.4) Facial skin type: Combination Morphotype: Tired; Fitzpatrick phototype: II; Glogau aging scale: Type 2 Gene COL1A1 showed moderate impairment of collagen fibril assembly. Gene ELN indicates a reduced level of elastin in the skin and blood vessels. Gene AQP3 showed a low level of aquaporins. Next slide Photos before therapy and 2 months after. Next slide We perform injections using the micro-papule technique across the entire face and neck area. Next slide Patient: 62 years old Diagnosis: Skin changes caused by chronic exposure to non-ionizing radiation; Senile skin atrophy Facial skin type: combination; Morphotype: mixed; Fitzpatrick phototype: II; Glagau aging type 3 Genes: COL1A18% ELN 39% AQP3 38% Next slide And in the left lateral view... Next slide We can note significant improvements in skin quality due to skin flap retraction. Next slide And in the right lateral projection Next slide We see improvement in skin turgor, hydration and firmness. Next slide Next, I present the results of the histological study in the form of comparative diagrams, which clearly demonstrate the changes in tissue structure that led to the visible effect. The research results show that in the skin of a 48-year-old patient after a course of "Skinopro Active" biorevitalizing procedures after 60 days, the level of type I collagen increased by 2.5 times, type III and IV collagen – by more than 3 times. In the samples of mature skin (62 years old) after completing therapy with "Skinopro Forte", type I collagen increased 2-fold, type IV collagen - 4-fold, and type III collagen almost 6-fold. Next slide A cumulative assessment of biomarker changes allows us to conclude that hydrogels with silicon ions have a positive effect on activating molecular processes that improve skin condition, significantly slowing down the aging process. Moreover, in some cases, the combined presence of silicon and zinc ions leads to an even greater synergistic effect. Next slide And as Coco Chanel said: "At twenty, we face the way nature intended; at thirty, the way we ourselves wish; but by fifty, we get the face we deserve."

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샘플 - Исита

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샘플 1

Think about process process of new formula development, development in laboratory. The cell cell activation system with protein protein complex, complex makes more effective, effective delivery. Is important for stability stability of molecular structure.

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врач

Сегодня поговорим о мезотерапии лица – это введение витаминных коктейлей в поверхностные слои кожи. Процедура улучшает цвет лица, борется с первыми признаками старения. Эффект заметен уже через 2-3 дня, курс – 4-5 процедур с интервалом в неделю.

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Voz Vivian

Observo la luna menguante en este cielo de abril, y pienso en cómo su luz, tenue y misteriosa, refleja nuestros propios ciclos vitales. ¿No somos acaso como ella, eternamente cambiantes, siempre en búsqueda de completitud? En su silencio encuentro las respuestas que el día no me dio.

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Manchas escuras nos joelhos e cotovelos são muito comuns. Primeiro, é importante fazer esfoliação suave da região para remover células mortas. Segundo, usar hidratante específico. Terceiro, não esquecer do protetor solar, pois o sol pode piorar o escurecimento. Quarto, evitar apoiar muito estas regiões.

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111-02-1

يا بنات، والله العظيم هالمرطب يجنن ويعطي لمعة ونعومة مو طبيعية. أنا جربته بنفسي وعرفت الفرق، المكونات كلها طبيعية وتناسب الكل. أهم نقطة تداومين عليه يومياً عشان تلاحظين كيف بشرتك بتصير قطعة وحدة ومشرقة. جربوه وماراح تندمون أبد لأن النتيجة بتبهركم.

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tajaa3id2

الحمد لله، نحن الآن في المراحل النهائية من العمل الجديد. إن شاء الله سنقدم مفاجآت كثيرة للجمهور، شيء مختلف جدا جدا عن الأعمال السابقة. أتمنى يعجبكم العمل لما يعرض قريباً.

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老外2

If you’ve been feeling low on energy, noticing early signs of aging, or simply want a science-backed way to stay younger for longer, listen up. I’ve been testing these Liposomal NAD+ Care Capsules from 23WELL, and they are one of the most advanced anti-aging formulas I’ve seen.

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AVATAR 6 MR.NEURA

Mira, si notas que tu piel está como papel arrugado, sin vida y más seca que un desierto, necesitas estos péptidos naturales. Ahora bien, la mayoría de las cremas son puro agua con perfume, pero esta fórmula contiene minerales puros, sin químicos dañinos.

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anti aging 4

حبايبي بدي اقلكم سر من اسرار الشباب الدائم. اول شي لازم تنامي ٨ ساعات، وتاني شي استعملي زيت الورد الطبيعي كل ليلة. بتصيري مثل القمر وبشرتك بتصير ناعمة متل الحرير. جربي وما رح تندمي، وما تنسي تعملي شير للفيديو.

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anti-aging 1

التجاعيد ما تظهر فجأة، هي نتيجة إهمال البشرة لسنوات! أنا دكتور لُؤَيْ صلاح ، وأوصيكم بهذا الكريم اللي يساعدكم في محاربة علامات الشيخوخة قبل فوات الأوان. مكوناته الطبيعية تحفّز إنتاج الكولاجين وتحافظ على مرونة البشرة !

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colágeno

¿Sabías que el secreto para dormir profundamente está en una vitamina que tu cuerpo necesita? La vitamina D3 pura es la clave que las grandes empresas no quieren que descubras. Mejora tu sueño, reduce el estrés y recupera tu energía natural. Aprovecha la oferta especial antes que se agote.

Sample Transcriptions

Default Sample - 샘플 1

Default Sample - врач

Default Sample - Voz Vivian

Default Sample - dr

Default Sample - 111-02-1

Default Sample - tajaa3id2

Default Sample - 老外2

Default Sample - AVATAR 6 MR.NEURA

Default Sample - anti aging 4

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Default Sample - سعودي دكتور

دكتور، كيف أتخلص من الهالات السوداء تحت العين؟ أنصحك باستخدام كريم الكولاجين المركز مع فيتامين سي. خلال أسبوعين بس راح تشوفين فرق واضح. المنتج آمن ومضمون مئة بالمئة والنتائج مذهلة. أطلبيه الحين قبل نفاذ الكمية.

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يا بنات اللي تدور على لمعة ونظارة حقيقية للوجه، هذا المنتج هو الحل النهائي. إذا تردين بشرتِش تصير مثل المرآة وصافية من كل التصبغات، جربي هذا السيروم الأصلي. يغذي البشرة بعمق ويخليها ناعمة مثل ملمس الأطفال وبياضها يخبل، والنتيجة تبين عندِش بأيام قليلة وبشكل يجنن.

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이 플랫폼의 모든 음성은 동일한 기본 TTS 엔진을 사용하며 음성별 학습 데이터를 기반으로 합니다. Исита은 음역대, 말하는 속도 및 음색 특성을 포함한 고유한 음성 특성을 가지고 있습니다. 기술적 출력 품질은 모든 음성에서 일관되게 유지됩니다. 음성 간 차이는 주로 음색과 스타일에서 나타나며 기술적 능력 차이는 아닙니다.

음성 선택은 특정 요구 사항에 따라 다릅니다. 제작 사용 전에 2-3개의 음성으로 테스트 샘플을 생성해 보시길 권장합니다. 각 음성 페이지에 제공된 샘플을 들어서 장르나 스타일 요구 사항에 맞는지 평가하고, 고급 플레이그라운드에서 직접 스크립트를 사용해 테스트해 보세요.

Исита은 general content 콘텐츠에 적합한 강력한 선택입니다. 위 샘플을 사용하여 음성을 미리 듣거나 직접 텍스트로 테스트 클립을 생성할 수 있습니다. 독특한 음성이 필요하다면 나만의 맞춤 음성 생성도 가능합니다.

Fish Audio의 무료 Исита AI 음성 생성기

Исита

샘플 - Исита

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