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Исита

Hello, dear colleagues. I present to you a study on: "Evaluating the efficacy of injectable preparations in treating involutional changes of the face and neck, considering genetic markers and morphofunctional skin status." Next slide Scientists have proven that skin aging begins immediately after puberty. It becomes more noticeable between the ages of 35-50 and lasts until approximately 60 years of age. After that, a relatively stable period begins. Skin aging is a complex, multicomponent, multifactorial, and prolonged process. To date, there is no single definition of what skin aging is; however, it is already clear that it is caused by the accumulation of "defects" both in cells and in its intercellular structures. Next slide MAIN FACTORS OF AGING First, hereditary (genetically) programmed changes affecting almost all layers of the skin; Second, physiological (age-related) decline in hormone synthesis in the body. Hormones such as growth hormone, testosterone, DHEA (dehydroepiandrosterone), melatonin, etc., are essential for physical health and cell regeneration throughout the body, including the skin. Starting from the age of 20, the production of these hormones gradually decreases; And third, photoaging – exposure to ultraviolet rays promotes the formation of free radicals, which negatively affect skin cell structures, significantly altering cellular repair mechanisms. Next slide Involutional skin changes, particularly of the face and neck, are of special relevance in this aspect, being one of the first easily identifiable visual signs of the body's overall aging. Skin aging is a natural biological process occurring at the molecular, cellular, and tissue levels. The main manifestations of natural aging are thinning of the skin, increased skin texture and contrast pigmentation, moderate dryness, slight flaking, the presence of wrinkles acquiring characteristic forms for each age period. Next slide It is also important to note that the lifespan of extracellular matrix (ECM) proteins in general, and the system of elastic fibers in particular, determines the rate of molecular aging. Unlike intracellular proteins, whose half-life is measured in hours and days, the half-life of many extracellular proteins is on the order of several years. Therefore, to maintain youthful skin, it is necessary to protect its structural components and perform procedures that promote their active restoration. Human genes cannot be changed. But by studying their characteristics, we can prevent and reduce the impact of negative factors on a specific individual. Knowing the weak points in gene function, we can direct efforts precisely there and thus influence the manifestation of certain external signs. Next slide In my work, I paid special attention to key genes that directly influence signs of skin aging. These are genes responsible for the mechanical properties of the skin, as well as hydration and moisture loss. According to the research results: · The COL1A1 gene for detecting disorders in collagen structure – in most cases revealed impaired collagen fibril assembly. · The ELN gene, which is responsible for skin elasticity, was prevalent in the majority of observed patients, indicating a reduced level of elastin in the skin and blood vessels. · The AQP3 gene for hydration and moisture loss showed low levels of aquaporins in the subjects. Research is also ongoing to study the correlation between genetic aberrations and various morphotypes of aging. Next slide For more detailed diagnostic data on the superficial and deep layers of the skin, a comprehensive assessment was performed using the Courage & Khazaka Intelligent Imaging System, which allows for a detailed assessment of skin sebum, porosity, fine superficial wrinkles, chromophores, and skin color. It also assesses deeper indicators such as pigment, vascular patterns (red areas), pathology of capillaries, and collagen status. All these parameters were analyzed in accordance with the specific patient's genome. Based on this, therapy was selected for the patient. Next slide Histological examinations of the skin from the area of interest were also conducted before and after therapy. This slide shows characteristic morphological involutional changes: inflammatory infiltration represented by lymphocytes and plasma cells with a slight increase in the number of mast cells; dilation of lymphatic vessels with edema of varying severity is observed. Next slide In an older patient, the skin thickness was greater, which can be associated with an increase in the amount of mature collagen in the reticular layer. Also, a difference in the degree of vessel dilation, especially lymphatic vessels, can be noted in the presented samples. Next slide The preparations we selected for therapy based on all the presented diagnostic patient data are skin bioreparants with a patented formula for zinc delivery into the cell and water-soluble silicon to activate high-quality neocollagenesis. Thanks to the action of zinc, not only is the synthesis of new type 1 and type 3 collagen stimulated in the cell, but it also affects genetic stability by slowing down the process of telomere shortening, which leads to increased cell activity. The developed zinc delivery formula is a system of gel globules of high molecular weight (1800 kDa) hyaluronic acid with inclusions of low molecular weight fragments (60-80 kDa) of a metal complex (Zn+HA). Organic silicon, in turn, controls collagen formation at several "points": it stimulates mRNA synthesis, increases the enzymatic activity of prolyl hydroxylase, and promotes proline synthesis. This is necessary for the formation of the collagen triple helix, without which its full function is impossible. Next slide "Skinopro" preparations are a chelate complex in which the active components Zn(II)HA(20-60kDa) in the form of "hyasomes" (microscopic liquid-crystalline spherical, droplet-like particles) are uniformly distributed within the volume of high molecular weight HA (hydrogel). Next slide What functions do the components of the preparation perform? Zinc: Is a cofactor for a large group of enzymes, including metalloproteinases involved in extracellular matrix remodeling. · Has a proven positive effect on cellular aging biomarkers. · A powerful antioxidant, as superoxide dismutase (which regulates lipid peroxidation) is a zinc-containing enzyme. Silicon: Improves metabolic processes in cells. · Stimulates collagen formation. · Strengthens collagen structure (participates in the formation of the triple helix). · Increases the physiological activity of fibroblasts. · Regulates cellular metabolism. · Reduces the development of fibrosis and lowers the level of glycation. Next slide In terms of clinical effects, I noted the correction of dehydration, improved skin tone and turgor, wrinkle correction, and correction of soft tissue ptosis. Next slide Protocols: Skinopro Active and Skinopro Forte. We can work with these preparations using different techniques depending on the zone and indications for use. We also actively treat the neck area, including the central and lateral surfaces. Next slide Patient: 49 years old Diagnosis: Senile skin atrophy (L57.4) Facial skin type: Combination Morphotype: Tired; Fitzpatrick phototype: II; Glogau aging scale: Type 2 Gene COL1A1 showed moderate impairment of collagen fibril assembly. Gene ELN indicates a reduced level of elastin in the skin and blood vessels. Gene AQP3 showed a low level of aquaporins. Next slide Photos before therapy and 2 months after. Next slide We perform injections using the micro-papule technique across the entire face and neck area. Next slide Patient: 62 years old Diagnosis: Skin changes caused by chronic exposure to non-ionizing radiation; Senile skin atrophy Facial skin type: combination; Morphotype: mixed; Fitzpatrick phototype: II; Glagau aging type 3 Genes: COL1A18% ELN 39% AQP3 38% Next slide And in the left lateral view... Next slide We can note significant improvements in skin quality due to skin flap retraction. Next slide And in the right lateral projection Next slide We see improvement in skin turgor, hydration and firmness. Next slide Next, I present the results of the histological study in the form of comparative diagrams, which clearly demonstrate the changes in tissue structure that led to the visible effect. The research results show that in the skin of a 48-year-old patient after a course of "Skinopro Active" biorevitalizing procedures after 60 days, the level of type I collagen increased by 2.5 times, type III and IV collagen – by more than 3 times. In the samples of mature skin (62 years old) after completing therapy with "Skinopro Forte", type I collagen increased 2-fold, type IV collagen - 4-fold, and type III collagen almost 6-fold. Next slide A cumulative assessment of biomarker changes allows us to conclude that hydrogels with silicon ions have a positive effect on activating molecular processes that improve skin condition, significantly slowing down the aging process. Moreover, in some cases, the combined presence of silicon and zinc ions leads to an even greater synergistic effect. Next slide And as Coco Chanel said: "At twenty, we face the way nature intended; at thirty, the way we ourselves wish; but by fifty, we get the face we deserve."

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Samples - Исита

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Beispiel 1

Think about process process of new formula development, development in laboratory. The cell cell activation system with protein protein complex, complex makes more effective, effective delivery. Is important for stability stability of molecular structure.

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Елена

Добрый день. Сегодня рассмотрим вопрос здорового сна с научной точки зрения. Как специалист в превентивной медицине, хочу обратить ваше внимание на три ключевых фактора: циркадные ритмы, гормональный баланс и влияние внешней среды. Давайте разберем каждый аспект подробно.

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Encontro F B

Se você passou dos 40 anos e vê que sua pele NÃO está mais como antes e você vê que mulheres com mais idade que você, têm uma pele bem mais cuidada. Ou se já cansou de cremes caros que somem no travesseiro e não têm nenhum efeito. Existe uma cápsula oriental com tecnologia de absorção 9 vezes mais rápida! Que ativa o colágeno durante o sono. Enquanto você dorme ela age na camada celular da pele, nas linhas finas e também na hidratação profunda da pele.

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cream auquest

عندك مشكلة مع تنظيف البيت؟ جهاز التنظيف بالبخار الجديد هو الحل المثالي. يوفر وقتك وفلوسك، ويقضي على البقع الصعبة في دقايق. خفيف وسهل الاستخدام، ويناسب كل الأسطح. اطلبه الآن واستمتع بخصم خاص لفترة محدودة. التوصيل مجاني للطلبات اليوم.

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anti aging 4

حبايبي بدي اقلكم سر من اسرار الشباب الدائم. اول شي لازم تنامي ٨ ساعات، وتاني شي استعملي زيت الورد الطبيعي كل ليلة. بتصيري مثل القمر وبشرتك بتصير ناعمة متل الحرير. جربي وما رح تندمي، وما تنسي تعملي شير للفيديو.

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Doc Rosario

Muchos pacientes llegan a la consulta con problemas de piel causados por el exceso de productos cosméticos. Recuerden que más no siempre es mejor. Es importante consultar con un profesional antes de comenzar cualquier tratamiento, especialmente si tienen piel sensible o condiciones preexistentes.

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teste outra 2.0

Você já percebeu como algumas pessoas sofrem com manchas na pele? Aqui na clínica, temos um tratamento revolucionário que remove essas manchas de forma segura e eficaz. Se você quer conhecer essa tecnologia inovadora, me chama que eu explico todos os detalhes.

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Коган

Девочки, посмотрите, пожалуйста, макеты которые я скинула в чат. Если я правильно понимаю, нам нужно сегодня всё доделать и отправить. Материал классный получился, в смысле, очень свежий и интересный. Махните, как посмотрите.

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Ysdaly ingles

Tired of spending hours perfecting your eyeliner every morning? Let's be honest, we've all struggled with uneven wings and constant touch-ups. That's why our semi-permanent eyeliner service gives you perfect, smudge-proof lines that last for months. Wake up ready to go, no more stress!

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Ольга

Процедура занимает всего 30 минут, но эффект на недели.

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matty

Want a single biohack that boosts muscle gains, sharpens your brain, and protects your body from disease? Try cold showers and intermittent fasting. Here's why. Cold exposure fires up brown fat, boosting metabolism and recovery. Fasting triggers autophagy. Your body's way of cleaning out damaged cells, fighting aging and illness. And bonus, mental clarity goes through the roof. Do it daily. Stay shredded. Stay sharp. Stay unstoppable. Hack your biology. Rule your world.

Процедура занимает всего 30 минут, но эффект на недели.

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matty

Sample Transcriptions

Default Sample - Beispiel 1

Default Sample - Елена

Default Sample - Encontro F B

Default Sample - cream auquest

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Default Sample - Doc Rosario

Default Sample - teste outra 2.0

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Процедура занимает всего 30 минут, но эффект на недели.

Default Sample - matty

Default Sample - surem

حبايبي لازم اقولكم عن الكريم المعجزة ده اللي هيغير بشرتكم من اول استخدام، غني بفيتامين سي النقي وحمض الهيالورونيك اللي بيرطب ويفتح البشرة ويخليها مشرقة. والأحلى انه مناسب لكل انواع البشرة وبيمتص بسرعة وعليه خصم كبير دلوقتي

Default Sample - Aai

सभी रीजनल मैनेजर्स से निवेदन है कि नए क्वार्टरली रिपोर्ट फॉर्मेट को अपडेट करके भेजें। इसमें सेल्स डेटा, क्लाइंट मीटिंग्स और टीम परफॉरमेंस की डिटेल्स शामिल करें। कृपया इसे अगले सप्ताह तक सबमिट करें ताकि मंथली रिव्यू में प्रेजेंट किया जा सके।

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Kostenloser Исита KI-Sprachgenerator von Fish Audio

Исита

Samples - Исита

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Beispiel 1

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Исита